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GQ1B Antibodies

Topic: Adult

Created on Sunday, October 5 2008 by jdmiles

Last modified on Sunday, October 5 2008.

The presence of GQ1B antibodies is associated with which of the following?

 
        A) Acute disseminated encephalomyelitis
 
        B) A syndrome of optic neuritis and transverse myelitis
 
        C) A syndrome of arreflexia, ophthalmoparesis, and ataxia
 
        D) Devic disease
 
        E) Myasthenia gravis
 

 


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This question was created on October 05, 2008 by jdmiles.
This question was last modified on October 05, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) acute disseminated encephalomyelitis

This answer is incorrect.


Acute disseminated encephalomyelitis (ADEM) is not associated with with antibodies to GQ1b ganglioside.  (See References)

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B) A syndrome of optic neuritis and transverse myelitis

This answer is incorrect.


Neuromyelitis (also called Devic disease) is a demyelinating disease in which the attacks are limited to transverse myelitis and optic neuritis. It is not associated with antibodies to GQ1b ganglioside.  (See References)

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C) A syndrome of arreflexia, ophthalmoparesis, and ataxia

This answer is correct.


The presence of GQ1B antibodies is associated with the Miller-Fisher syndrome (MFS). MFS is a variant of Guillain-Barre syndrome. Patients with MFS have minimal weakness, and usually a good prognosis. The defining features of MFS are ataxia, ophthalmoparesis, and arreflexia. Patients with MFS frequently have a positive titer for antibodies against GQ1b ganglioside.  (See References)

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D) Devic disease

This answer is incorrect.


Neuromyelitis optica (also called Devic disease or NMO) is a demyelinating disease in which the attacks are limited to transverse myelitis and optic neuritis. It is not associated with antibodies to GQ1b ganglioside.  (See References)

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E) Myasthenia gravis

This answer is incorrect.


Myasthenia gravis is not associated with antibodies to GQ1b ganglioside.  (See References)

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References:

1. Allan H. Ropper, Robert H. Brown. . New York : McGraw-Hill Medical Pub. Division, 2005. (ISBN:007141620X)Advertising:
2. Floyd, T. (1999). "Bear-inflicted human injury and fatality." Wilderness Environ Med, 10(2) 75-87. (PMID:10442155)
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adult
GQ1B Antibodies
Question ID: 100508132
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 10/05/2008
Modified: 10/05/2008
Estimated Permutations: 3600

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