Last modified on Monday, February 11 2013.
Courtesy of Dr. Mark Cohen
This section was obtained from the frontal neocortex of a patient with behavioral variant dementia. Which is the following antibodies would react most strongly with the neuronal cytoplasmic inclusion?
Glial fibrillary acidic protein is the predominant intermediate filament within astrocytes, but is not present with in neurons. (
Alpha-synuclein is the predominant protein found within Lewy bodies, but is not identified within Pick bodies. (
Inclusions immunoreactive with FUS (fused in sarcoma) are found within a subset of patients with frontotemporal lobar degeneration. These patients may demonstrate basophilic intraneuronal inclusions, but not Pick bodies. (
Although inclusions immunoreactive with TDP-43 comprise the most common pathological form of frontotemporal lobar degeneration, The protein is not found within Pick bodies. (